The goal of the CanBioSe project is to strengthen international and cross-sectoral collaboration through the exchange of new ideas and the transfer of knowledge from research institutions to the market and vice versa in the field of optical nanostructured metal oxide biosensors for disclosure cancer cells. The project's interdisciplinary research and innovation objectives aim to develop a new portable tool for early detection of cancer that could address important health problems in the EU. One-dimensional (1D) nanofiber polymers will be deposited by electrospinning. Metal oxide photonic nanomaterials (ZnO, ZnO/Al2O3, Au/ZnO and ZnO/Au nanolaminates) will coat 1D nanofibers. Metal oxides and nanoparticles will be deposited by atomic layer deposition (ALD) and electrophoresis. Bioselection layers will be created by stopping certain antibodies on the surface of the biosensor. Photoluminescence and optical spectroscopy will be used to record the biosensor signal. Biosensor tests will be carried out on cancer cells (in people with chronic lymphocytic leukemia and acute lymphoblastic leukemia). The biosensors will be integrated with a microflow system to minimize the size and ease of use of the detection system. Project partners will conduct research and training in the areas of nanotechnology, surface functionalization, bioengineering, microflow and biosensors, market analysis and commercialization. Research and training within the project, for experienced scientists and young researchers, will strengthen their personal skills and enable them to enrich their professional experience, for example, through new scientific articles and conference presentations. The project provides for ongoing cooperation between partners, based on the participation of students and the preparation of innovative research projects. Ultimately, it is planned to disseminate the results obtained during the project not only among scientists.